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Sonography-guided Resection of Brain Mass Lesions: a Prospective, Single Arm Clinical Trial
Objective of the study is to determine possibilities of intraoperative sonography in detecting of various brain mass lesions, assessing extent of their resection and define indications to use ultrasound-guided needle or ultrasound wire-guided port.
Intraoperative sonography is usially used in neurooncology to detect brain tumors and exclude their remnants. A few studies describe it's usage while removing hematomas or vascular malformations. Ultrasound is the only method allowing to observe brain tissue in real time. It is chip and doesn't violate surgical workflow. Main disadvantages of sonography are lengthy learning curve and poorer image quality compared to magnetic resonance imaging. Novel acoustic coupling fluid, contrast-enhanced ultrasound and elastography expanded it's effectiveness. Meanwhile problems of locating of isoechogenic lesions with poor margins and elimination of artefacts are steel actual. Objective of the study is to determine possibilities of intraoperative sonography in detecting of various brain mass lesions, assessing extent of their resection and define indications to use ultrasound-guided needle or ultrasound wire-guided port. A surgeon will intraoperatively locate mass lesion and assess extent of it's resection with sonography. Ultrasound scanning will be performed through the same surgical approach or at a distance through enlarged craniotomy, periodically or permanently. To facilitate approach to subcortical and deep small mass lesions ultrasound-guided needle or ultrasound wire-guided port will be used.
Age
18 - 100 years
Sex
ALL
Healthy Volunteers
No
Sklifosovsky Institute of Emergency Care
Moscow, Russia
Start Date
September 1, 2022
Primary Completion Date
August 31, 2027
Completion Date
August 31, 2027
Last Updated
May 16, 2025
100
ESTIMATED participants
Sonography
DEVICE
Lead Sponsor
Sklifosovsky Institute of Emergency Care
NCT02879071
NCT06724029
Data Source & Attribution
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View ClinicalTrials.gov Terms and ConditionsNCT05777499