Atorvastatin Use and Portal Hypertension in Patients With Hepatitis B Virus-related Liver Cirrhosis: A Randomized Controlled Trial

Exclusion Criteria

• •1. Hepatitis C or HIV co-infected person
• •2. Those who continuously drink more than the standard (alcohol intake exceeding 20g per day)
• •3. In case of decreased liver function with Child Pugh score of 7 or higher
• •4. History of decompensated cirrhosis: history of ascites, spontaneous bacterial peritonitis, hepatic coma, varicose bleeding, hepatic nephrotic syndrome
• •5. If there is a history of cancer (except for cases where there is no recurrence for 5 years after treatment due to early solid organ tumors (early gastric cancer, thyroid cancer))
• •6. If there is a serious comorbidity whose life expectancy is estimated to be less than 3 years
• •7. In case of chronic kidney disease estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73 m2
• •8. If portal vein thrombosis is diagnosed
• •9. Previous intrahepatic portal vein shunt intervention or liver transplantation
• •10. A history of statin administration within the last 2 years
• •11. In case of side effects from previous statin administration (drug-related hepatotoxicity, muscle toxicity, allergic reaction, etc.)