Protein and Exercise Training in Chronic KIDNEY Disease

You may be eligible if

• 1. In order to be eligible to participate in this study, a patient with CKD must meet all of the following criteria:
• * (e)glomerular filtration rate (GFR) \<45 ml/min/1.73m2
• * Age: 18 - 80 y
• * Able to provide written informed consent
• 2. In order to be eligible to participate in this study, a healthy subject must meet all of the following criteria:
• * (e)GFR \>60 ml/min/1.73m2 without albuminuria
• * Age: 18 - 80 y
• * Able to provide written informed consent
• 1\. A potential subject with CKD who meets any of the following criteria will be excluded from participation in this study:
• Insulin-dependent diabetes mellitus or two or more oral glucose lowering medications
• Active inflammatory disease / malignancies
• Uncontrolled hypertension (\>160/100mm Hg), unstable angina pectoris, or arrhythmia
• Pulmonary disease restricting exercise performance (e.g. COPD)
• A history of neuromuscular problems
• Cognitive Impairment
• Diagnosed GI tract diseases / dysphagia
• Allergies to milk proteins / Lactose intolerance
• Pregnancy
• Hospitalization \<1 months prior to study period
• Participation in any structured exercise program
• Any medications known to affect protein metabolism (i.e. corticosteroids or prescription strength acne medications).
• Use of DOAC, vitamin-K-antagonist, or multiple anticoagulants.
• Dialysis treatment or previous kidney transplantation
• 2\. A potential healthy subject who meets any of the following criteria will be excluded from participation in this study:
• Insulin-dependent diabetes mellitus or two or more oral glucose lowering medications
• Active inflammatory disease / malignancies
• Uncontrolled hypertension (\>160/100mm Hg), unstable angina pectoris, or arrhythmia
• Pulmonary disease restricting exercise performance (e.g. COPD)
• A history of neuromuscular problems
• Cognitive Impairment
• Diagnosed GI tract diseases / dysphagia
• Allergies to milk proteins / Lactose intolerance
• Pregnancy
• Hospitalization \<1 months prior to study period
• Participation in any structured exercise program
• Any medications known to affect protein metabolism (i.e. corticosteroids or prescription strength acne medications).
• Use of DOAC, vitamin-K-antagonist, or multiple anticoagulants.