Anticoagulation Therapy Timing in Atrial Fibrillation After Acute and Chronic Subdural Hematoma

Exclusion Criteria

• •1. aSDH requiring decompressive craniectomy
• •2. Mechanical heart valve or moderate to severe mitral stenosis
• •3. Known chronic coagulopathy (elevated INR \>1.5 or PTT\>40s after anticoagulant reversal, thrombocytopenia with platelet count \<50x109/L) that is not amenable to reversal
• •4. \>37 days has elapsed since initial diagnosis without recruitment into the trial
• •5. Active gastroduodenal ulcer, urogenital or respiratory tract hemorrhage
• •6. Known pregnancy or breastfeeding
• •7. Indication for therapeutic anticoagulation other than AF
• •8. Pre-randomization brain CT at 2-4 weeks after initial diagnosis or surgery date reveals significant recurrence requiring surgical drainage
• •9. Known to be non-compliant with prior anticoagulant
• •10. MRP decides to restart Warfarin (as opposed to DOACs) as prophylactic anticoagulant as part of standard therapy for the patient after cSDH or aSDH