Therapeutic Evaluation of Low-dose IL-2-based Immunomodulatory Approach in Patients With Early AD

Exclusion Criteria

• •Subject with a psychiatric evolutionary and/or badly checked.
• •Subject with a grave, severe or unstable pathology (left to the judgement of the investigator) the nature of which can interfere with the variables of evaluation.
• •Epileptic subjects
• •Subject under guardianship or curatorship
• •Subject presenting contraindications to the MRI
• •Known or supposed history (\< or = 5 years) of severe alcoholism or misuse of drugs
• •Vascular, inflammatory or expansive, visible lesion in the MRI, which can interfere on the criteria of diagnosis.
• •No health insurance
• •Women of childbearing potential: a woman is considered of childbearing potential (WOCBP), i.e. fertile, following menarche and until becoming post-menopausal unless permanently sterile. Permanent sterilisation methods include hysterectomy, bilateral salpingectomy and bilateral oophorectomy. A postmenopausal state is defined as no menses for 12 months without an alternative medical cause.
• •History of auto-immune disease
• •History within the past 10 years of a primary or recurrent malignant disease
• •Diagnosis or history of other possible etiology of dementia, including but not limited to other neurodegenerative disorders (FTD, LBD, VaD, HD, PD, PSP-CBD).
• •Renal dysfunction at inclusion, clearance \<30 mL/min
• •Chronic hepatic diseases as indicated by liver function tests abnormalities
• •Abnormal thyroid function
• •Therapeutic trial within 1 year preceding the first study period, or participation in a trial with active or passive immunization against amyloid if patient was assigned to the active treatment arm.
• •Clinically significant evidence of Active viral infection (CMV, EBV, HCV, HBV, TPHA-VDRL, HIV)
• •Current or medical history of severe cardiopathy,
• •\- Severe dysfunction in a vital organ
• •Patients with White Blood Count (WBC) \< 4.000/mm3; platelets \< 100.000/mm3; hematocrit (HCT) \< 30%.
• •Patients with serum bilirubin and creatinine outside normal range.
• •Patients with organ allografts.
• •Patients who are likely to require corticosteroids