The Effects of Cold Adaptation on Skin Blood Flow, Hand Function, and Comfort in Healthy Adults

Exclusion Criteria

• •History of cold injuries of any severity (e.g., frostbite, trench foot, chilblains).
• •Raynaud's syndrome.
• •Cold-induced asthma/bronchospasm
• •Previous hand/finger injuries that impair dexterity and hand function.
• •Metal hardware (plates/screws) in the forearms and hands.
• •Current use of medications or dietary supplements that could alter cardiovascular, thermoregulatory, or vascular control (e.g., anti-hypertensives, statins).
• •Known allergies to medical adhesives.
• •Heart, lung, kidney, muscle, or nerve disorder(s)
• •A planned MRI during the study or within 2 days after completing a cold test.
• •Women who are pregnant, planning to become pregnant, or breastfeeding.
• •Not willing to have small areas of skin on the body shaved (if deemed necessary for attachment of study instrumentation)