Drug Interaction Study of ASC42 With Atorvastatin

Exclusion Criteria

• •Females with childbearing potential if no dual safe anticontraception method is provided.
• •Male subjects whose female partner is currently pregnant or wanting to become pregnant or sexually active subjects if methods of contraception are not used during the trial and for 30 days following their final study drug.
• •ALT or AST \>ULN or Direct bilirubin \>ULN
• •Total Bilirubin \>ULN with any single parameters of ALT, AST, ALP or GGT \> ULN
• •Elevated creatine kinase (CK) at screening (one repeat test allowed)
• •Any surgical or medical condition which might significantly alter the absorption, distribution, metabolism, or excretion of drugs, or may jeopardize the safety of the participants.
• •Platelet count \<150,000/mcL or INR\> 1.2
• •History of , or current electrocardiogram abnormalities, arrythmias or heart valve diseases.
• •History of drug or food allergies that caused severe hypersensitivity.
• •History of intolerance to or adverse event reaction to a statin, or history of myopathy.