InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

Inclusion Criteria

• •Participants to be included in this study include the following (note that this list is not comprehensive but gives examples of precursor conditions for each organ type):
• •1-Hereditary risk for cancer including
• •* Carriers of known or previously unrecognized pathogenic germline variants of cancer predisposing genes
• •* Individuals with personal or family history suggestive of elevated cancer risk (this may include individuals who have negative genetic testing results or have not elected to undergo testing)
• •* Individuals with a clinically based diagnosis of a Cancer Predisposition Syndrome (examples, neurofibromatosis, Fanconi Anemia, Ataxia-Telangiectasia)
• •* Hereditary Cancer Prediction Model-based elevated cancer risk
• •* Others at risk for specific cancers by virtue of exposure, obesity, gender, race and ethnicity, HPV exposure (for H\&N cancer for example), etc.
• •Exposed High Risk including
• •* Childhood cancer survivors with treatment exposures associated with increased risk of cancer
• •* Adult cancer survivors with treatment exposures associated with increased risk of cancer
• •* Documented high level exposure to group 1 IARC carcinogens
• •* Thoracic: individuals at risk for lung cancer including but not exclusive of the following criteria: Age \>50, Smoking history of \>15 pack years, First-degree relative history of lung cancer or COPD
• •* alcoholic liver disease (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis
• •Precursor Lesions including
• •* Breast: ductal/lobular carcinoma in situ (CIS) and atypical hyperplasia
• •* GI: Barrett's esophagus, Pancreatic precursor lesions, colonic dysplasia/adenomata, nonalcoholic fatty liver (NAFL), nonalcoholic steatohepatitis (NASH), cirrhosis
• •* GU: High grade prostatic epithelial neoplasia, and high-grade bladder urothelial dysplasia/carcinoma in situ,
• •* Lung: Adenomatous hyperplasia
• •* H\&N: high-risk oral precancerous diseases
• •* Skin: Class II melanocytic lesions. Squamous dysplasia
• •* Heme malignancies: CHIP, CCUS, ICUS, MGUS, SMM, SWM, MBL (spell these out), Low grade lymphomas
• •* Thoracic: Lung nodules detected on screening CT that prompt further follow-up
• •* GYN: STIC lesion (serous tubal intraepithelial carcinoma), Endometrial intraepithelial neoplasia, Cervical and endocervical carcinoma in situ, vulvar intraepithelial neoplasia
• •* Pediatric histologic diagnoses sometimes associated with development of malignancy: Nephrogenic rests, benign bone lesions with risk of malignant degeneration (Giant cell tumor, osteochondroma), Spitz nevus, and others.
• •FAMILY MEMBERS or healthy individuals