Dutch Intracerebral Hemorrhage Surgery Trial

Exclusion Criteria

• •1. Considerable pre-stroke dependency in activities of daily living, defined as a pre-stroke mRS ≥3;
• •2. ICH-GS score ≥11;
• •3. Hemorrhage due to hemorrhagic transformation of an infarct;
• •4. Untreated coagulation abnormalities, including INR \>1.3 (point of care measurement allowed), treatment with heparin and treatment with factor Xa inhibitors. Patients on vitamin K antagonist can be included after correction of the INR, and patients on dabigatran (direct thrombin inhibitor) can be included after reversal of dabigatran with idarucizumab;
• •5. Moribund (e.g. coning, bilateral dilated unresponsive pupils), or progressively deteriorating clinical course with imminent death;
• •6. Pregnancy (note: most patients will be beyond childbearing age);
• •7. DIST-INFLAME sub-study: patients that use immunosuppressive or immune-modulating medication.