Cross-linked Volume-stable Collagen Matrix Versus Connective Tissue Graft At Implant Site.

Exclusion Criteria

• •General contraindications for dental and/or surgical treatments
• •Concurrent or previous immunosuppressant, bisphosphonate or high dose corticosteroid therapy
• •Inflammatory and autoimmune disease of oral cavity
• •History of myeloma, respiratory tract cancer, breast cancer, prostate cancer or kidney cancer requiring chemotherapy or radiotherapy within the past five years
• •Radiotherapy of head area
• •Disease or condition affecting connective tissue metabolism (e.g. disease of arteries in the operating zone, bone metabolic diseases, alcohol abuse, treatment with anticoagulants)
• •Any systemic diseases that affect bone metabolism (e.g thyroid dysfunction, autoimmune disease)
• •Untreated acute periodontal disease
• •Patients who smoke more than 10 cigarettes/day will be excluded from the study
• •Diabetes
• •Allergy to the collagen
• •Pregnant or lactating women
• •Women of child bearing age, not using a highly effective method of birth control
• •Participation in an investigational device, drug or biologic study within the last 24 weeks prior to the study start