Topical Cannabidiol Application and Skin Vascular Reactivity

Exclusion Criteria

• •Abnormal resting heart rate (\<60 or \>100 bpm) or BP (systolic \<100 or \>129 mmHg, diastolic \<60 or \>100 mmHg) values
• •Rash, skin disease, disorders of pigmentation
• •Known skin allergies
• •Diabetes
• •Nicotine use (e.g. smoking, chewing tobacco, vaping, etc.)
• •Illegal drug use
• •Recent (within the last 30 days) CBD users either topical or oral
• •Allergy or hypersensitivity to investigational agents
• •Women who are pregnant or breastfeeding