An Evidence-Based Focal Cryotherapy Protocol for Focal Ablation of Intermediate Risk Prostate Cancer

Primary Objective: • To determine the effectiveness of an evidence-based focal cryotherapy ablation by measuring negative in-field recurrence rate at 6-months post-ablation. Secondary Objectives: * To determine quality of life following focal prostate cancer ablation using validated questionnaires (EPIC-26, AUA symptoms score, SHIM). * To establish PSA kinetics post-evidence-based focal cryotherapy ablation. * To determine rates of out of field recurrence on 6-month biopsy following focal cryotherapy ablation. * To determine MRI findings post-focal cryotherapy ablation, including those related to prostate and surrounding periprostatic fat volume. * To determine rate of progression and re-intervention collected as part of standard of care treatment for 5-year following study treatment. * To describe financial toxicity associated with focal prostate cancer treatment using cryotherapy. * To describe the incidence and severity of complications within 30-days after the study focal ablation treatment. * To describe imaging findings on PSMA PET MRI performed in a subset of men after standard of care focal cryotherapy prior to 6-month biopsy.