Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Michigan
With
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Age
21–45
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Participants must have the following criteria:
* oligomenorrhea-anovulation
* spontaneous intermenstrual periods (if not on hormonal birth control or birth control that alters menstrual cycle timing) of \< 21 days or \> 35 days or a total of 8 or fewer menses per year
* if on hormonal birth control or birth control that alters menstrual cycle timing, a history of irregular periods
* and hyperandrogenism
* If not on hormonal birth control or birth control that alters menstrual cycle timing: Total testosterone ≥ 35 ng/dL OR free testosterone \> 4.0 pg/ml OR free androgen index \> 1.5 OR in-person scoring for hirsutism, based on the modified Ferriman-Gallwey score, if attending an in-person assessment or based on the self-assessment (if not attending an in-person assessment) with a score of ≥ 4 considered hirsutism;
* If on hormonal birth control or birth control that alters menstrual cycle timing: Tests within the past 10 years showing the above or study team's in-person assessment of hirsutism as above.
If no medical records to confirm (most recent test from within the last 10 years in range), tests for diagnosis will be ordered:
Willingness to be randomized to either dietary approach
Measured HbA1c at baseline of 5.3%-9.0%
You may not be if
Primary
* Patients with non-PCOS etiologies of anovulation and hyperandrogenism (Cushing's disease, thyroid dysfunction, elevated prolactin levels, signs of a congenital adrenal hyperplasia organic intracranial lesion like a pituitary tumor, or suspected adrenal or ovarian tumor secreting androgens)
* Menopause or removal of the ovaries
* history of type 1 diabetes
* use of medications prescribed for weight loss or psychostimulants known to affect weight
* participation in another weight loss program or intervention
* use of glucose lowering medications other than metformin or medications known to affect metabolism, such as chronic oral corticosteroids
* pregnant or planning to become pregnant during the intervention period
* Breastfeeding or less than 6 months postpartum
* previous bariatric surgery or planning to have bariatric surgery during the study period
* Self-reported blood disorders that influence HbA1c, including frequent blood transfusions, phlebotomy, anemia, hemoglobinopathy, and polycythemia
Ability
* inability to read, write, or speak English
* inability to provide informed consent
* adherence to a vegan or vegetarian diet
* difficulty chewing or swallowing
* no influence over what foods are purchased, prepared, and/or served or inability to follow dietary advice due to lack of money or other resources
* above weight limit (500 lbs) for DEXA
* self-report of alcohol or substance use disorder within the past 5 years, including current at-risk drinking based on an AUDIT score of 15 or higher (but those who score a 15 or higher and have this criterion as their only reason for ineligibility may be assessed by a clinical psychologist for alcohol use disorder and if deemed to not have such a disorder would be eligible for the trial)
Safety
* Renal disease: BUN \> 30 mg/dL or serum creatinine \> 1.4 mg/dL in our screening blood tests or history of kidney stones
* untreated eating disorder or unstable serious mental illness (such as depression (score of 20 or greater on the PHQ8), bipolar or schizophrenia with psychosis)
* use of warfarin
* chronic kidney disease, stage 4 or higher
* Any other concerning values in baseline labs (we will plan to send the participant to their PCP and allow the participant to return for later enrollment if labs are no longer concerning) Examples:
