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Effect of Sedation Strategy on Duration Mechanical Ventilation in Patient After Cardiac Surgery | Clinical Trials | Clareo Health

COMPLETEDNA

Effect of Sedation Strategy on Duration Mechanical Ventilation in Patient After Cardiac Surgery

Comparing Effect of Propofol, Dexmedetomidine and Their Combination on Duration Mechanical Ventilation in Patient After Cardiac Surgery

NCT05451121•Anesthesia Research Group UA

View on ClinicalTrials.gov

Summary

There is a direct relationship between the sedative agent and the duration of ventilation.

Detailed Description

Sedation and sedative agent have direct correlation to the mechanical length. As known mechanical length could increase length of the hospital stay (LOHS) and mortality rate. The right sedative agent can decrease the length go the mechanical ventilation. The goal of the research to compare 3 sedation strategies and their influence to the duration of mechanical ventilation.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Multi vascular lesions of the coronary arteries according to coronary angiography;
•Heart valve damage was confirmed by, which is subject to surgical correction (aortic stenosis of III degree with a gradient on the aortic valve of more than 42 mmHg, aortic insufficiency III, mitral valve stenosis II-III, mitral regurgitation II-III)
•Age of patients from 18-80 years; • Patient consent to participate in the study;

Exclusion Criteria

•Refusal to participate;
•* Hypersensitivity to propofol, dexmedetomidine;
•* Prolonged mechanical ventilation in case of surgical complications (bleeding, inadequate perfusion of the myocardium);
•* Occurred ischemic stroke;
•* History of the ischemic stroke;
•* History of the neurodegenerative diseases;
•* History of the mental disorders;
•* Use of neuroleptics, antidepressants for the last 5 years;
•* History of the cardiac surgery in the past;
•* Patients with chronic pulmonary disease (GOLD 3-4)
+10 more criteria

Locations (1)

Anesthesia department Medical Network Dobrobut

Kyiv, Ukraine

Key Dates

Start Date

July 1, 2017

Primary Completion Date

July 1, 2019

Completion Date

July 1, 2019

Last Updated

July 11, 2022

Enrollment

356

ACTUAL participants

Conditions

Respiratory FailureMechanical Ventilation ComplicationSedation Complication

Interventions

Propofol

DRUG

Dexmedetomidine

DRUG

Propofol and dexmedetomidine

DRUG

Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications

NCT07186933

Postoperative Pulmonary AtelectasisPostoperative Pulmonary Complications+8 more

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RECRUITINGNA

Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units

NCT05686850

Post Extubation Respiratory Failure

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 11, 2022Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Effect of Sedation Strategy on Duration Mechanical Ventilation in Patient After Cardiac Surgery

Inclusion Criteria

Exclusion Criteria

Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications

Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units

Global Physiotherapy in ICU Patients With High Risk Extubation Failure

A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score

Evaluating the Safety and Performance of the MiniLung Petite Kit in Neonatal and Pediatric Patients With Acute Respiratory and Cardiac Failure

Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults