Durvalumab and Grid Therapy for Non-small Cell Lung Cancer in Progression During or After Treatment With PACIFIC Regimen

Any of the following because this study involves an investigational agent whose genotoxic, mutagenic, and teratogenic effects on the developing fetus and newborn are unknown:

* Pregnant persons

* Nursing persons

* Persons of childbearing potential OR able to father a child who are unwilling to employ adequate contraception

Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety of the prescribed regimens

Active autoimmune disease requiring systemic treatment, documented history of severe autoimmune disease, or a syndrome that requires systemic steroids or immunosuppressive agents

* NOTE: Exceptions are allowed for:

* Vitiligo

* Resolved childhood asthma/atopy

* Intermittent use of bronchodilators or inhaled steroids

* Daily steroids at dose of =\< 10mg of prednisone (or equivalent)

* Local steroid injections

* Stable hypothyroidism on replacement therapy

* Stable diabetes mellitus on non-insulin therapy

* Sjogren's syndrome

Uncontrolled intercurrent illness including, but not limited to:

* Ongoing or active infection requiring systemic therapy

* Interstitial lung disease

* Serious, chronic gastrointestinal conditions associated with diarrhea (e.g., Crohn's disease or others)

* Known active hepatitis B (i.e., known positive hepatitis B virus \[HBV\] surface antigen \[HBsAg\] reactive)

* Known active hepatitis C (i.e., positive for hepatitis C virus \[HCV\] ribonucleic acid \[RNA\] detected by polymerase chain reaction \[PCR\])

* Known active tuberculosis (TB)

* Symptomatic congestive heart failure

* Unstable angina pectoris

* Unstable cardiac arrhythmia or

* Psychiatric illness/social situations that would limit compliance with study requirements (e.g., substance abuse)

History of myocardial infarction =\< 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias

Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm

Hypersensitivity to durvalumab or any of its excipients

Previous adverse event attributed to durvalumab or other PD-1 or PD-L1 directed therapy that led to drug discontinuation

History of grade \>= 3 immune-related adverse event or any grade of immune-related neurologic or ocular adverse event while receiving immunotherapy

* Note: Patients who had endocrine adverse events =\< grade 2 are allowed to enroll if they are stable on appropriate replacement therapy and asymptomatic

Other active malignancy \< 6 months prior to registration

* EXCEPTIONS: Non-melanotic skin cancer, papillary thyroid cancer, prostate cancer, or carcinoma-in-situ of the cervix, or others curatively treated and now considered to be at less than 30% risk of relapse

Major surgical procedure (as defined by the Investigator) within 28 days prior to the first dose of investigational product (IP)

* Note: Local surgery of isolated lesions for palliative intent is acceptable

History of allogenic organ transplantation

History of active primary immunodeficiency

Known to have tested positive for human immunodeficiency virus (HIV) (positive HIV 1/2 antibodies) or active tuberculosis infection (clinical evaluation that may include clinical history, physical examination and radiographic findings, or tuberculosis testing in line with local practice)

Known active hepatitis infection, positive hepatitis C virus (HCV) antibody, hepatitis B virus (HBV) surface antigen (HBsAg) or HBV core antibody (anti-HBc), at screening. Participants with a past or resolved HBV infection (defined as the presence of anti-HBc and absence of HBsAg) are eligible. Participants positive for HCV antibody are eligible only if polymerase chain reaction is negative for HCV RNA. Adjust wording as necessary and consider evaluating at screening for studies with known hepatotoxicity or other relevant requirements

Receipt of live attenuated vaccine within 30 days prior to the first dose of IP

* Note: Patients, if enrolled, should not receive live vaccine whilst receiving IP and up to 30 days after the last dose of IP

Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab. The following are exceptions to this criterion:

* Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra articular injection)

* Systemic corticosteroids at physiologic doses not to exceed \<\<10 mg/day\>\> of prednisone or its equivalent

* Steroids as premedication for hypersensitivity reactions (e.g., computed tomography \[CT\] scan premedication)

What this study is about