Cardiovascular Risk Factors and Cognitive Trajectories

Exclusion Criteria

• •1. Aged \<65;
• •2. had a history of dementia or MMSE score \< 18 at baseline;
• •3. Without more than once cognitive function assessment during the follow-up;
• •4. Refused to participate the survey.
• •For the neuroimaging sample, who would be enrolled by this study:
• •1. Severe visual or hearing impairment, difficult to complete cognitive function assessment;
• •2. Had contraindications to magnetic resonance examination, such as claustrophobia, cardiac pacemaker and artificial heart valve;
• •3. Had cardiovascular diseases (such as myocardial infarction and unstable angina pectoris), severe respiratory diseases, malignant tumors, renal failure and other serious physical diseases;
• •4. Had diseases that could affect cognitive function, such as hypothyroidism, syphilis, vitamin B12 deficiency and anemia;
• •5. Had a history of any mental disease;
• •6. Had a history of cerebrovascular disease, or obvious space occupying lesions in the brain revealed by magnetic resonance examination;
• •7. Refused to participate the survey.