Effects of Dapagliflozin and Metformin on Vascular Function in Newly-Diagnosed Treatment-Naive Type 2 Diabetes

Exclusion Criteria

• •1. History of ketoacidosis or any other conditions causing acidosis e.g. Alcohol dependence
• •2. Has a history of urinary tract infections or is at risk for urinary tract infections (e.g prostatomegaly, vesicoureteric reflux, kidney stones)
• •3. Patients on corticosteroids or immunosuppressive agents
• •4. Patients known to have HIV infection and/or on anti-retroviral agents
• •5. Patients with typical clinical features suggestive of T1DM (young onset with no family history of diabetes or first presentation as DKA were excluded). The endocrinologist (PI or co-I) will look at the patient profile to confirm diagnosis of T2DM.
• •6. Has severe liver dysfunction
• •7. Considered inappropriate by investigators due to any other reason.
• •8. Female participant who is pregnant, lactating or planning pregnancy during the course of the trial.
• •9. Significant renal impairment.
• •10. Scheduled elective surgery or other procedures requiring general anaesthesia during the trial.
• •11. Participants who have participated in another research trial involving an investigational product in the past 12 weeks.
• •12. Participants who have a history of Peripheral Arterial Disease or peripheral vascular disease or complains of lower limb claudication pain.
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