Evaluating the Analytical Equivalency of Serum and Whole Blood Samples Run on the MeMed Key® Platform (Perseverance Study)

Exclusion Criteria

• •1. HIV, HBV, active HCV, or active Tuberculosis infection (self-declared or known from medical records).
• •2. Suspicion and/or confirmed diagnosis of infectious gastroenteritis/ colitis.
• •3. Active inflammatory disease (e.g., IBD, SLE, JIA, RA, Kawasaki, other vasculitis).
• •4. Pregnancy- self reported or medically confirmed.
• •5. Active malignancy.
• •6. Congenital or acquired immune deficiency (CID).
• •7. A proven or suspected infection on presentation with Mycobacterial (e.g., Tuberculosis, MAC), parasitic or fungal (e.g., Candida, Histoplasma, Aspergillus) pathogen.
• •8. Significant trauma or burns in the last 7 days.
• •9. Patients that have undergone major surgery in the last 7 days.
• •10. Current treatment with immune-suppressive or immune-modulating therapies, including without limitations:
• •1. Administration of P.O.\\IV\\IM high dose steroids \>1mg/kg/day prednisone (or equivalent) at some point in the past 10 days or daily continuous use of steroids \> 0.25 mg/kg/day in the past 7 days
• •2. Monoclonal antibodies, anti-TNF agents
• •3. Intravenous immunoglobulin (IVIG)
• •4. Cyclosporine, Cyclophosphamide, Tacrolimus, Azathioprine, Methotrexate
• •5. G/GM-CSF, Interferons.