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Prehospital Analgesia INtervention Trial (PAIN)

NCT05437575·11 sites·ClinicalTrials.gov

What this study is about

Take this into the appointment.

Saves the questions and what to expect into your notes, next to the visit they belong to.

Keep this study

Jason Sperry, MD
CONTACT
412-802-8270 sperryjl@upmc.edu

Lead

Jason Sperry

With

United States Department of Defense

Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

You may be eligible if

Transport after injury to a participating PAIN Trauma center
2\. Patient with compensated shock as defined by Shock Index (SI) ≥0.9 or Heart Rate (HR) ≥115.
Intravenous pain medication indicated (CPOT≥2, NRS≥5) prior to arrival at the trauma center

You may not be if

No IV access
Age \<18 years
Females \<50 years of age
SBP\>180 mmHg at time of enrollment
Advanced airway management prior to first dose administration
Known allergy to fentanyl citrate or ketamine hydrochloride
Known prisoner
Objection to study voiced by subject or family member at scene
Pain treatment contraindicated by local protocol
Wearing a "NO PAIN STUDY" bracelet

The record

StatusRecruiting

PhasePhase 3

Taking part994

StartedNov 2023

UpdatedMar 9, 2026

Conditions

Traumatic Injury

Where11

University of California, San Diego
San Diego, California, United States
Zuckerberg San Francisco General Hospital
San Francisco, California, United States
Cooper University Health Care
Camden, New Jersey, United States

Clareo Health | Prehospital Analgesia INtervention Trial (PAIN)