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COMPLETEDNANCT05411822

Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment

The purpose of this research study is to investigate the relationship between light, the thickness of the pigment at the back of your eye, melatonin levels, and memory. The study will investigate whet...

Lead sponsor: Icahn School of Medicine at Mount Sinai•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Icahn School of Medicine at Mount Sinai

Collaborators

National Institute on Aging (NIA)

Eligible enrolled subjects will be exposed to 4 different lighting conditions in addition to one dark control condition. There will be 5 study session and each one will last for 90 minutes and will be separated by one week. Subjects will collect 3 saliva samples, each one 30 minutes apart for melatonin levels during each study session.

Age

55 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•mild cognitive impairment
•age matched healthy control
•macular pigment density either \< 0.3 or \> 0.5

Exclusion Criteria

•extensive brain vascular disease
•Parkinson's disease
•bipolar disorder
•seasonal depression
•diabetes
•high blood pressure
•obstructing cataracts
•macular degeneration
•diabetic retinopathy
•use of melatonin supplements
•use of beta blockers
•use of sleep medications
•use of antidepressant medication

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: June 24, 2025Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment36

Start dateJun 2021

Last updatedJun 24, 2025

Condition

Mild Cognitive Impairment Alzheimer Disease

Locations shown

Light and Health Research Center at Mount Sinai

Menands, New York

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 24, 2025Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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