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A Randomised Controlled Trial Comparing Convergent Hybrid Ablation to Catheter Ablation in Patients With Persistent Atrial Fibrillation and Heart Failure
A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) and Heart Failure
The objective of this randomized study is to evaluate the safety and efficacy of Convergent hybrid ablation when compared to standard catheter ablation in patients with non-paroxysmal AF and heart failure. Patients will be randomised in a 1:1 ratio. The primary efficacy endpoint will be freedom from persistent atrial arrhythmia (measured from the end of a 3-month blanking period up to 24 months (12 and 24 months).
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Ashford & St Peters Hospital NHS Trust
Chertsey, United Kingdom
Epsom General Hospital
Epsom, United Kingdom
Cromwell Hospital
London, United Kingdom
Royal Surrey County Hospital
London, United Kingdom
St Anthonys Hospital
London, United Kingdom
St Georges at Kingston Hospital
London, United Kingdom
St Georges University of London
London, United Kingdom
Start Date
June 25, 2022
Primary Completion Date
May 1, 2026
Completion Date
October 1, 2027
Last Updated
November 28, 2025
120
ESTIMATED participants
AtriCure EPi-Sense-AF Guided Coagulation System +/- Atriclip
DEVICE
Endocardial Catheter Ablation
DEVICE
Lead Sponsor
St. George's Hospital, London
NCT03546374
NCT07301190
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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View ClinicalTrials.gov Terms and ConditionsNCT06765356