The Poor Responders Study

Exclusion Criteria

• •History of any medical, psychological or other condition, or use of any medications, including over-the-counter products, which, in the opinion of the investigators, would either interfere with the study or potentially cause harm to the volunteer.
• •Without access at home to a telephone or other factor likely to interfere with ability to participate reliably in the study.
• •Pregnancy or breastfeeding.
• •Unable to maintain adequate contraception for the duration of the study and for one month afterwards.
• •History of hypersensitivity to any of the components of the subcutaneous infusions.
• •Donated blood during the preceding 3 months or intention to do so before the end of the study.
• •Any other co-morbidity that would compromise the validity of the study or the safety of the participant such as heart failure or clinically apparent cardiovascular disease.
• •Anatomical or endocrinological pathology causing poor weight loss or weight regain
• •Uncontrolled hypertension (systolic blood pressure of 160 mmHg or above and/or diastolic blood pressure of 100 mmHg or above)
• •Participation in a research study within the last two months.
• •Unable to speak English (this is relevant to answering the psychological questionnaires)