Nasal Microbiota Transfer Therapy in Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)

Exclusion Criteria

• •Aged \<18 or \>80 years
• •Allergy to amoxicillin or clavulanate potassium and Clarithromycin.
• •Excessive Nasal polyposis
• •Antibiotic treatment in the last 4 weeks
• •Patients with a history supporting a diagnosis of immune deficiency will be tested (Immunoglobulin A (IgA), Immunoglobulin M (IgM), Immunoglobulin G (IgG) and IgG subclasses, MBL) and /or are immunocompromised due to disease and / or medication ( e.g., insulin dependent diabetes mellitis, systemic corticosteroids)
• •Patients who live with someone who is severly immunocompromised.
• •Patients with cystic fibrosis or ciliary dyskinesia
• •Patients who have been on an active investigational therapy within 2 months of screening
• •Patients who have clinically significant laboratory abnormalities
• •Patients who are pregnant, breast feeding or planning to become pregnant during the study
• •Patients who are not willing to use a double barrier method of contraception during the study that is:-
• •1. females must use contraceptive pill or Intra-uterine device (IUD) or similar and condoms
• •2. males must use condoms and spermicidal gel
• •Patients currently on any medication that may affect the results in an unpredictable manner
• •The patient does not agree to comply with or is unable to meet all study requirements for the duration of the study period
• •Patients deemed by the investigator to be unsuitable for participation in the study
• •Patients who have had Coronavirus-19 (COVID-19) within the last month.
• •Findings in the prestudy pathogen scan that makes the donor unsuitable. Prestudy pathogen scan: Prior to first donation, the donors will be tested for HIV, Human T-lymphotropic virus 1 and 2, Hepatitis B and C, Syphilis, Tuberculosis, Herpes Simplex (HSV 1 and 2), Varicella Zoster (VZV), Cytomegalovirus (CMV), Epstein-Barr virus (EBV), Methicillin-resistant Staphylococcus aureus (MRSA) and a standard panel for sinonasal pathogens (Pneumococci, H. Influenza, Beta-streptococci and M. Catarrhalis).
• •Donors who have had COVID-19 within the last 2 months.
• •If the donor is positive for Herpes Simplex, CMV or EBV they will be considered unsuitable as a donor for a patient negative for the same pathogen. If the donor is positive for any other pathogen they will be considered unsuitable as a donor entirely.