A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors

This is a single-center, open-label, dose-escalation study consisting of three distinct treatment cohorts for patients with CEA-positive advanced malignant solid tumors: Cohort 1 (Intravenous infusion): A dose-escalating (3+3 design) study with 4 dose levels,: 1.0×106, 3.0×106, 5.0×106 CAR+ cells/kg and 7.0×106 CAR+ cells/kg. Cohort 2 (Intraperitoneal injection): A dose-escalating (3+3 design) study with 3 dose levels：1.0×106, 3.0×106,and 5.0×106 CAR+ cells/kg. Cohort 3 (FAST CAR-T Intraperitoneal infusion): A dose-escalating study (3+3 design) with 4 dose levels: 2.0×10⁵, 3.0×10⁵, 4.0×10⁵, and 5.0×10⁵ CAR+ cells/kg.