Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study

Inclusion Criteria

• •1. Males and females African Americans ≥ 65 years of age.
• •2. Part of the ABCD2 longitudinal cohort, protocol 844047, of the PMC/ADCC with consensus conference designation of normal cognition.
• •3. ABCD2 longitudinal visit must be completed or scheduled to be completed within 1 year prior to the \[18F\]AV-1451 TAU PET scan.
• •4. A brain MRI must be performed within 1 year prior to their study \[18F\]AV-1451 TAU PET scan date and be deemed of adequate quality that the scan may be used for study analysis, including 3T high-resolution imaging of medial temporal lobe structures.
• •5. An amyloid PET scan completed or scheduled within 1year of their study \[18F\]AV-1451
• •6. Women must be post-menopausal or surgically sterile.