Metagenome Resilience in Experimental Gingivitis

Exclusion Criteria

• •infectious or systemic diseases that may be unduly affected by participation in this study
• •extensive crown or bridge work and/or rampant decay at the discretion of the examiner
• •wear removable partial dentures, a fixed/removable orthodontic appliance
• •diabetes
• •history of xerostomia, salivary gland disease, head and neck radiotherapy, Sjögren's syndrome, mucocutaneous disorders of the oral cavity, vesicobullous disorders of the oral cavity
• •smoking or use of e-cigarettes within the last 2 years
• •current use of prescription or over-the-counter medications that could affect salivary flow, at the discretion of the examiner
• •lack of capacity to be able to consent to the research project and/or inability to follow study instructions
• •pregnant by medical history or nursing
• •currently undergoing or requiring extensive dental, orthodontic or implant treatment, or treatment for peri-implantitis
• •treatment with antibiotics for any medical or dental condition within 4 weeks prior to enrolment
• •scale and polish within 4 weeks prior to enrolment
• •long term use of antibiotics or non-steroidal anti-inflammatory drugs (prophylactic low dose aspirin is permitted though)
• •evidence of drug induced gingival overgrowth
• •participation in a dental research study within the previous 20 days.
• •Unilever personnel and personnel in the University department performing the study