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COMPLETEDNANCT05383300

Intranasal Oxytocin in Antiosocial Personality Disorder and Psychopathy

A pharmacoimaging study of oxytcoin in antisocial personality disorder and psychopathy

Lead sponsor: King's College London•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

King's College London

Collaborators

Father Flanagan's Boys' Home

Using a double-blinded, placebo controlled design, we explored similarities and differences in i) an important component of empathic processing (neural response to facial emotional expressions) and ii) decision-making in violent men with ASPD+/-Psychopathy, compared to healthy non-offenders (NO; n= 21 across studies), with placebo and after acute application of intranasal oxytocin, using functional Magnetic Resonance Imaging (fMRI).

Age

18 - 60 years

Sex

MALE

Healthy Volunteers

Yes

Inclusion Criteria

•Male
•Aged 18-60
•IQ greater than 70 as defined by the Wechsler Abbreviated Scale of Intelligence (WASI-II).
•Violent offenders:
•Offenders with convictions for violent crimes (murder, rape, attempted murder, grievous and actual bodily harm) who met DSM-5 criteria for antisocial personality disorder (Structured Clinical Interview for DSM-5 Personality Disorders (SCID-5 PD) Psychopathy or non-psychopathy subgroup based on Psychopathy Checklist- Revised (PCL-R; (Hare, 2003))- score of 25 as the threshold for psychopathy in this English population.
•Healthy non-offenders:
•Non-offenders with no personality disorder

Exclusion Criteria

•history of major mental disorders (bipolar 1, bipolar 2, major depression or psychotic disorders)
•self-reported neurological disorders
•head injury resulting in loss of consciousness for 1 hour or longer
•severe visual or hearing impairments
•contraindications to MRI

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 20, 2022Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment72

Start dateMay 2017

Last updatedMay 20, 2022

Condition

Antisocial Personality Disorder

Locations shown

Insititue of Psychiarty, Psychology and Neuroscience

London, Nottinghamshire

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 20, 2022Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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