1. Pregnant or breastfeeding

2. Radiologic evidence of distant metastases

3. Prior history and treatment for any cancer within the past year or has another active cancer, with the exception of non-melanoma skin cancer

4. Prior initiation of chemotherapy, radiation therapy, or surgery for pancreatic cancer

5. Neuropathy \> grade 2

6. History of bone marrow or organ transplant

7. Blood transfusion within 1 month of enrollment

8. Medical condition that would place the patient at risk as a result of blood donation, such as bleeding disorder

9. Serious medical condition that may adversely affect ability to participate in the study

Observational Study of ctDNA in Resectable and Borderline Resectable Pancreatic Cancer