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Pharmacokinetics, Pharmacodynamics and Safety of Ziltivekimab Versus Placebo in Chinese Participants With Chronic Kidney Disease and Systemic Inflammation
This study is conducted to see how the ziltivekimab works in the body of Chinese people with chronic kidney disease and systemic inflammation. Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body. Participants' chance of getting ziltivekimab or placebo is the same. Participants will get their study medicine in a pre-filled syringe. The study doctor or staff will do 3 injections of study medicine during clinical visits. The study is expected to last for about 6 months. Participants will have blood and urine samples taken at all of the clinic visits. Participants will have their heart examined using electrodes (electrocardiogram). Women cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Peking University Third Hospital
Beijing, Beijing Municipality, China
Beijing Hospital
Beijing, Beijing Municipality, China
Chinses People's Liberation Army General Hospital-Nephrology
Beijing, Beijing Municipality, China
Zhongda Hospital Southeast University-Nephrology
Nanjing, Jiangsu, China
Zhongda Hospital Southeast University-Neurology
Nanjing, Jiangsu, China
The First Affiliated Hospital of Soochow University-Endocrinology
Suzhou, Jiangsu, China
The First Affiliated Hospital Of Soochow University
Suzhou, Jiangsu, China
Start Date
May 30, 2022
Primary Completion Date
June 12, 2024
Completion Date
September 2, 2024
Last Updated
December 31, 2025
24
ACTUAL participants
Ziltivekimab
DRUG
Placebo
DRUG
Lead Sponsor
Novo Nordisk A/S
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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