1. Clinically diagnosed with relapsing remitting multiple sclerosis (RRMS), primary progressive multiple sclerosis (PPMS), clinical isolated syndrome (CIS), or radiologically isolated syndrome (RIS)

2. Clinical MS relapse and/or new MRI lesion(s) within the preceding 2 years

3. Positive pregnancy test

4. Gadolinium contrast allergy

5. Acute or chronic kidney disease with eGFR \<30 ml/min/1.73m2

6. Pacemaker or other MRI contraindications per American College of Radiology guidelines

7. Intravenous iron sensitivity

8. Serum ferritin and transferrin saturation above age-adjusted upper limit of normal (if serum ferritin is above normal, but transferrin saturation is normal, the subject is NOT excluded)

Novel Imaging Markers in SPMS

What this study is about