Adjunctive Bright Light Therapy in Patients With Bipolar Depression and Eveningness

Exclusion Criteria

• •1. Major Depressive Disorder fulfilling the Seasonal Pattern Specifier of the DSM-V (Seasonal Affective Disorder).
• •2. A past history of rapid-cycling within the past twelve months or a Young Mania Rating Scale more than 12 at screening
• •3. A current or past history of schizophrenia, mental retardation, organic mental disorder; or current substance use disorder.
• •4. Presence of psychotic symptoms or substantial suicidal risk as judged by the clinician and/or screening instruments.
• •5. Presence of contraindications to bright light therapy: for example, history of light induced migraine/ epilepsy; current use of photosensitizing medications such as St. John's wart; presence of eye disease: e.g. retinal blindness, severe cataract, glaucoma, and photosensitive skin condition e.g. systemic lupus erythematosus
• •6. Significant medical condition/ hearing impairment/ speech deficit leading to incapability of completing clinical interview.
• •7. Regular shift-workers or trans-meridian flight in the past 3 months or during study
• •8. Enrolment in another clinical trial of an investigational medicinal product or device.
• •9. Receiving regular psychotherapy.