Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Age
18–35
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Patients diagnosed with schizophrenia with onset in the past 5 years, diagnosed through a structured clinical interview (SCID-5 CV)
Aged between 18 and 35 years
Patients requiring treatment with lurasidone (independently from the inclusion in the present study) or that are being treated with lurasidone for 2 weeks maximum.
no other psychotropic treatment during the 2 weeks preceding the beginning of the study
Acceptance of the informed consent form for the participation to the study
For women in childbearing age, negative pregnancy test (urine or blood Beta HCG) performed before the start of the treatment and use of a highly efficient contraceptive method (such as progestin contraceptives, estrogen-progestin contraceptives, IUD, IUS, bilateral fallopian tube blockage, vasectomized partner, sexual abstinence) throughout the duration of the treatment.
Aged between 18 and 35 years
Acceptance of the informed consent form for the participation to the study
You may not be if
presence of other psychiatric and/or neurological diagnoses
previous antipsychotic treatment, except for patients that have been treated with other antipsychotics for less than a month and that have not been treated in the two weeks preceding the beginning of the trial, who are considered eligible.
contraindications to lurasidone treatment (as per summary of product characteristics)
intellectual disability
alcool or substance abuse in the previous 6 months
presence of absolute or relative contraindications to MRI
underage patients
no negative pregnancy test or no use of a highly efficient contraceptive method
pregnancy (if a patient becomes pregnant during the course of the study, the subject will be excluded from the study)
presence of psychiatric and/or neurological disorders
family history of psychiatric disorders in 1st-degree relatives
intellectual disability
other medical conditions at the time of the study
family history of hereditary neurological diseases
alcool or substance abuse
presence of absolute or relative contraindications to MRI
underage patients
no negative pregnancy test or no use of a highly efficient contraceptive method
pregnancy (if a subject becomes pregnant during the course of the study, the subject will be excluded from the study)
Clareo Health | Impact of Structural and Myelin Abnormalities on Cognitive Impairments in Recent-onset Schizophrenia - Before and After Lurasidone Treatment (MARYLU)
