A Phase II Study of Pre-Op SRS Followed by Surgical Resection for Brain Metastases

Inclusion Criteria

• •1. Histologic proof or unequivocal cytologic proof of solid tumor malignancy. This may be obtained from either the primary site or any metastatic site
• •2. Solid tumor brain metastases
• •3. Age≥ 18 years
• •4. Karnofsky Performance Status ≥70
• •5. Patient must have agreed to undergo surgical resection to manage at least 1 brain metastasis
• •6. Maximum tumor diameter of index lesions \<5 cm. (Index lesion defined as the brain metastasis which will undergo surgical resection)
• •7. Brain MRI within 1 month of initiation of brain SRS
• •8. No prior whole brain radiotherapy (WBRT) or radiation therapy directed to index brain metastases
• •9. Patients of childbearing potential (male or female) must practice adequate contraception due to possible harmful effects of radiation therapy on an unborn child
• •10. Patient must have the ability to understand and the willingness to sign a written informed consent document
• •11. All patients must be informed of the investigational nature of this study and must be given written informed consent in accordance with institutional and federal guidelines
• •12. Patients receiving prior SRS for brain metastases in other locations of the brain are eligible
• •13. Patients with multiple brain metastases planned for surgical intervention are eligible for this study. Each individual brain metastasis will be treated