Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Regeneron Pharmaceuticals
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Have a histologically confirmed diagnosis of FL grade1-3a as defined in the protocol
2. Have been r/r to at least 2 lines of systemic therapy for FL grade 1-3a, including an anti-CD20 antibody and an alkylating agent as defined in the protocol
You may not be if
4. Have measurable disease on cross sectional imaging (defined as at least 1 bi-dimensionally measurable nodal lesion ≥1.5 centimeter \[cm\] in the greatest transverse diameter \[GTD\] regardless of the short axis diameter) documented by diagnostic imaging (computed tomography \[CT\], or magnetic resonance imaging \[MRI\]) recorded on or during the 8 weeks prior to index date
5. Have FL treatment response assessed according to Lugano classification of malignant lymphoma or are deceased prior to opportunity for assessment
1. Evidence of histological transformation (HT) prior to index date (ie, evolution to a clinically aggressive non-hodgkin's lymphoma (NHL) such as diffuse large B-Cell lymphoma (DLBCL) as defined in the protocol
2. Primary central nervous system (CNS) lymphoma or known involvement by non-primary CNS non-Hodgkin's lymphoma (NHL) on or prior to index date
3. History of allo-stem cell transplant (SCT) prior to index date
4. Received anti-CD20 x anti-CD3 bispecific therapy prior to index date
5. Another malignancy in the 5 years on or prior to index date, with the exception of non-melanoma skin cancer and B-NHL
6. History of neurodegenerative condition or CNS movement disorder on or prior to index date
7. Evidence of significant cardiovascular disease on or prior to index date
8. Evidence of significant pulmonary disease, defined as obstructive pulmonary disease and a history of symptomatic bronchospasm on or prior to index date.
9. Eastern Cooperative Oncology Group (ECOG) performance status \>1 on or prior to index date.
10. Inadequate organ function as defined in the protocol
