Genetically Engineered Natural Killer (NK) Cells With or Without Atezolizumab for the Treatment of Non-small Cell Lung Cancer Previously Treated With PD-1 and/or PD-L1 Immune Checkpoint Inhibitors

Inclusion Criteria

• •Documented informed consent of the participant and/or legally authorized representative
• •* Assent, when appropriate, will be obtained per institutional guidelines
• •Agreement to allow the use of archival tissue from diagnostic tumor biopsies
• •Age \>= 18 years
• •Eastern Cooperative Oncology Group (ECOG) 0 or 1
• •Lung non-small cell carcinoma (NSCLC) patients with advanced, metastatic, or recurrent disease, previously treated with a PD-1 or PD-L1 immune checkpoint inhibitor, either as single agent or in combination with chemotherapy or other immunotherapy or experimental agents
• •Radiographically demonstrable tumor progression treatment on or after therapy with a PD-1/PD-L1 immune checkpoint inhibitor
• •Preserved organ function and recovery of prior drug related toxicities (except alopecia or grade 2 anemia) to grade 1 or better
• •No cytotoxic chemotherapy or immunotherapy over the three weeks prior to lymphodepletion
• •Histologically confirmed non-small cell lung cancer
• •Measurable disease as per Response Evaluation Criteria in Solid Tumors (RECIST) criteria 1.1
• •Fully recovered from the acute toxic effects (except alopecia) to =\< grade 1 to prior anti-cancer therapy
• •Absolute neutrophil count (ANC) \>= 1,500/mm\^3
• •Hemoglobin (Hgb) \>= 8 g/dl
• •Platelets \>= 100,000/mm\^3
• •Total bilirubin =\< 1.5 x upper limit of normal (ULN)
• •Aspartate aminotransferase (AST) =\< 1.5 x ULN
• •Alanine aminotransferase (ALT) =\< 1.5 x ULN
• •Alkaline phosphatase (AP) =\< 1.5 x ULN
• •Creatinine clearance of \>= 60 mL/min per 24-hour urine test or the Cockcroft-Gault formula
• •If not receiving anticoagulants: International normalized ratio (INR) OR prothrombin (PT) =\< 1.5 x ULN
• •If on anticoagulant therapy: PT must be within therapeutic range of intended use of anticoagulants
• •Seronegative for human immunodeficiency virus (HIV) antigen (Ag)/antibody (Ab) combo, hepatitis C virus (HCV), active hepatitis B virus (HBV) (surface antigen negative)
• •* If positive, hepatitis C ribonucleic acid (RNA) quantitation must be performed
• •Women of childbearing potential (WOCBP): Negative urine or serum pregnancy test. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required
• •Agreement by females and males of childbearing potential to use an effective method of birth control or abstain from heterosexual activity for the course of the study through at least 06 months after the last dose of protocol therapy
• •* Childbearing potential defined as not being surgically sterilized (men and women) or have not been free from menses for \> 1 year (women only)