Neoadjuvant Breast Cancer Time Restricted Eating

Inclusion Criteria

• •Inclusion Criterion
• •1. Patient must be ≥ 18 years of age at time of consent and must be able to understand and provide informed consent.
• •2. BMI 25-40 at time of enrollment.
• •3. Patients must have an ECOG performance status of 0 or 1.
• •4. Patient must have a recent diagnosis of histologically confirmed primary invasive breast carcinoma.
• •1. Multifocal or contralateral DCIS or invasive breast cancers are allowed if the breast cancers meet the same eligibility criteria for ER/PR and HER2.
• •2. Oligometastatic disease is allowed if treating physician recommends standard neoadjuvant chemotherapy.
• •5. Tumor status must be HER2 negative per ASCO/CAP guidelines (determined by local testing).
• •6. Patients must have clinical stage I-III (utilizing TNM criterion) at diagnosis.
• •7. Clinical T size must be ≥ 1.5cm if there is no radiographic or clinical evidence of axillary lymph node involvement. Any size tumor is allowed if axillary lymph nodes appear to be involved.
• •8. Patient must be willing and able (have no contraindication) to receive recommended standard neoadjuvant therapy consisting of at least 16 weeks of planned neoadjuvant chemotherapy.
• •a. Acceptable regimen includes doxorubicin and cytoxan followed by a taxane The schedule will be determined by treating physician. Carboplatin and pembrolizumab can also be added to the neoadjuvant chemotherapy regimen if determined to be appropriate by treating physician.
• •9. Patients must have organ and marrow function adequate for initiating neoadjuvant chemotherapy as determined by their treating physician.
• •10. Patient must be willing and able (have no contraindication) to participate in TRE consisting of 16 weeks
• •11. Women of childbearing potential and sexually active males must use accepted and effective method(s) of contraception or abstain from sexual intercourse for the duration of their participation in the study and for 6 months after the last study intervention.
• •12. Patient must have a personal email address, an internet-capable device, and the ability/ willingness to read and reply to email every day for the duration of the study.