Oral Vancomycin Vs Placebo in the Prevention of Recurrence of Clostridioides Difficile's Infection

Exclusion Criteria

• •Woman of childbearing age, pregnant woman, or breastfeeding woman
• •Hypersensitivity to vancomycin
• •Inability to comply with study protocol
• •Critically ill condition or life expectancy less than 30 days
• •Patients with diagnosed inflammatory bowel disease or with any conditions that produce chronic diarrhea
• •Fulfilment of the criteria for diarrhea or diagnosis of CDI at the time of assessment for eligibility or in the previous 3 days
• •Therapy with oral vancomycin or any other agent with activity against C. difficile for \>48 hours in the previous 3 days;.
• •Prophylaxis with oral vancomycin or any other agent with activity against C. difficile within the 70 days before the assessment for eligibility
• •Systemic antibiotic therapy for 72 hours or more before the recruitment
• •Ongoing enrolment in another RCT evaluating the effectiveness of other drugs
• •Estimated use of systemic antibiotic therapy for more than 4 weeks