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COMPLETEDNA

PET - PEEP by EIT for Acute Respiratory Distress Syndrome Trial

EIT-guided PEEP Titration Versus Low PEEP/FiO2 Table for ARDS: a Multicenter, Randomized, Controlled Trial

NCT05307913•Peking Union Medical College Hospital

Summary

This study is a multicentric randomized controlled study.The objective of this study is to compare the prognosis of patients with ARDS between EIT-oriented individualized PEEP and traditional lower PEEP/FiO2 table-oriented PEEP strategy.

Eligibility

Age

18 - 90 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Intubated, mechanically ventilated patients with diagnosis of ARDS according to ARDS Berlin standard by attending doctor

Exclusion Criteria

•1. Age \< 18 years old and \> 90 years old;
•2. Pregnancy;
•3. EIT contradictions (presence of pacemaker or automatic implantable cardioverter defibrillator);
•4. Severe intracranial hypertension;
•5. Pneumothorax, pneumomediastinum, subcutaneous emphysema or at high-risk for pneumothorax (e.g., pneumatocele, interstitial lung disease);
•6. Unstable hemodynamic status intorerable to lung recruitment and PEEP titration, judged by an attending intensivist; (This may be a transient criterion, since patients meeting this criterion might be included later if hemodynamics improves)
•7. End status of disease;
•8. Patients or their families refused to participate in the study

Locations (1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Key Dates

Start Date

April 10, 2022

Primary Completion Date

February 27, 2025

Completion Date

May 10, 2025

Last Updated

January 29, 2026

Enrollment

676

ACTUAL participants

Conditions

ARDS, Human

Interventions

EIT-guided PEEP

OTHER

Table-guided PEEP

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 29, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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PET - PEEP by EIT for Acute Respiratory Distress Syndrome Trial

Inclusion Criteria

Exclusion Criteria

Alveolar Macrophage Programming Following Endotoxin Exposure

Depth of Sedation and Its Impact on Cerebrovascular Reactivity in Acute Respiratory Distress Syndrome: a Pilot Analysis

Regional Citrate Anticoagulation for RRT During V-V ECMO

Direct Topical Lung T3 Treatment to Improve Outcome & Sequelae of COVID-19 Acute Respiratory Distress Syndrome

Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers: A Case-control Study Using Both Retrospective and Prospective Samples

The Effect pf Goal-directed De-escalation in ARDS on Organ Function and Mortality