Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma

Exclusion Criteria

• •Breastfeeding or pregnant patients: for women of childbearing age, a urine pregnancy test will be performed
• •Patients with ocular or mucosal melanoma of metastatic ocular melanoma
• •Patients with metastatic melanoma not treated with immunotherapy (i.e. treated with a combination of targeted therapies).
• •Contraindication to the initiation of immunotherapy: HIV and/or HCV and/or HBV positive, active autoimmune disease (chronic inflammatory bowel disease such as ulcerative colitis, Crohn's disease, vasculitis, etc.), patients with autoimmune motor neuropathy (such as Guillain Barré syndrome).
• •Vulnerable patients: minors, adults under guardianship or curatorship, deprived of liberty
• •Vulnerable persons (minors, patients under guardianship or curatorship, deprived of liberty, under court protection, etc.).
• •A psychiatric or addiction history that will compromise the patient's ability to consent and follow the proper protocol procedures
• •Any other clinical finding that, in the opinion of the principal investigator, could interfere with the results of the study or pose a risk to the patient during the study.