Xeomin Treatment of Glabellar Lines Using OLD Versus COLD

Exclusion Criteria

• •Brow or eyelid ptosis, excessive dermatochalasis, deep dermal scarring, thick sebaceous skin, or an inability to substantially lessen upper facial rhytides, even by physically spreading them apart.
• •Facial asymmetry including, in the opinion of the investigator, significant asymmetry with active contraction or at rest of the frontalis muscle.
• •Medical condition that may increase the subject's risk of exposure to botulinum toxin, including diagnosed myasthenia gravis, Lambert-Eaton Syndrome, amyotrophic lateral sclerosis, or any other disease that might interfere with neuromuscular function.
• •Profound atrophy/excessive weakness of muscles in target areas of injection.
• •History of facial nerve palsy.
• •Infection at the injection site or systemic infection.
• •Presence of inflammation at the proposed injection site.
• •Previous cosmetic surgery to the upper face (eg, periorbital surgery, brow lift, eyelid or eyebrow surgery), tissue grafting, or tissue augmentation with silicone or fat or other permanent fillers, or planning a facial cosmetic procedure during the study period.
• •Subjects have been treated in the upper face (forehead lines, glabellar lines, crow's feet lines) within 1 year prior to the Baseline/Day 1 Visit with botulinum toxin therapy of any serotype.
• •Noncompliance with the proper washout periods for prohibited medications/procedures.
• •Subjects on topical retinoid therapy and/or topical hormone cream applied to the face, who have not been on a consistent dose regimen for at least 6 months prior to enrollment and who are unable to maintain a consistent dose regimen during the study.
• •Oral retinoid therapy within 1 year prior to study enrollment.
• •Current enrollment in an investigational drug or device study or participation in such a study within 30 days of entry into this study.
• •Females who are pregnant, breastfeeding, or planning a pregnancy during the study
• •Females of childbearing potential not using a reliable means of contraception.
• •Known allergy or sensitivity to the study treatment or its components.
• •Known immunization or hypersensitivity to any botulinum toxin serotype.
• •Prior exposure to or anticipated need for treatment with botulinum toxin of any serotype for any reason during the study (other than study treatment).
• •Evidence of recent alcohol or drug abuse.
• •The subject has a condition or is in a situation which, in the investigator's opinion, may put the subject at significant risk, may confound the study results, or may interfere significantly with the subject's participation in the study.