Antiorbital Calcium in Chronic Conditions

Exclusion Criteria

• •Individuals with a current or past diagnosis of permanent AF
• •Individuals with any thyroid or parathyroid disorders, or current use of thyroid medication for any reason.
• •Individuals with chronic kidney or liver disease, cancer, colorectal disease, and "other rare disorders".
• •Individuals with a current diagnosis of Congestive Heart Failure (CHF).
• •Individuals with a current or past diagnosis of Traumatic Brain Injury (TBI), thromboembolism, or Cerebrovascular Accident (CVA)/Stroke.
• •Use of dihydropyridine or non-dihydropyridine calcium channel blockers for any reason
• •If diagnosed with atrial fibrillation, not on a stable dose of anti-coagulant or anti-platelet prescription medications (i.e., consistent dose for a minimum of three months)
• •Abnormalities in coagulation studies (e.g., INR ≤ 2 or ≥ 3.0) or hypercalcemia at the clinical screening visit.
• •Blood pressure ≥ 140/90 mmHg at the clinical screening visit.
• •Current involvement or within 14 days prior to screening of a significant diet or weight loss program (such as NutriSystem, Jenny Craig, Atkin's or other low-carb diet programs) or very low-calorie liquid diet programs (such as Optifast, Medifast, and/or HMR)
• •Hospitalization (for any reason other than a scheduled medical procedure unrelated to atrial fibrillation, hypertension, or osteoarthritis) within 3 months prior to screening
• •Cardiac surgery within 3 months prior to screening
• •Malignancy within the last 5 years (with the exception of basal cell carcinoma, squamous cell carcinoma, and/or carcinoma in situ of the cervix)
• •Are allergic to corn.
• •Women who are lactating, pregnant or planning pregnancy within the next six months
• •Intake of ≥ 2 standardized alcohol-containing beverages per day, 14 per week, or ≥4 in any single day within the past 14 days.
• •Women who experience menstrual periods, who are sexually active and are unwilling to use an appropriate form of contraception during the duration of the trial.
• •Smoking tobacco or nicotine products (combusted or vaporized)
• •Use of illicit drugs/substances (such as but not limited to cocaine, phencyclidine (PCP), and methamphetamine) within 14 days of screening
• •Currently participating in another interventional research study, or participated in another interventional research study within 14 days of screening
• •Do not have an active primary care provider or specialist (i.e., cardiologist, rheumatologist, orthopedist, etc.) managing their atrial fibrillation, hypertension, or osteoarthritis.
• •Current use of: dietary supplements or medications utilized for chelation purposes (i.e., ethylenediaminetetraacetic acid; EDTA), or of chemotherapeutic agents.
• •MoCA score of 16 or less upon screening.