Utidelone in Third-line and Above Treatment of Small Cell Lung Cancer

Inclusion Criteria

• •Histologically diagnosed small cell lung cancer (except for small cell lung cancer mixed with other pathological types);
• •The expected survival period is not less than 3 months;
• •Second-line therapy (excluding maintenance therapy) and above with disease progression or recurrence of small cell lung cancer;
• •Patients who have not received chemotherapy, radiotherapy, surgery, targeted therapy and immunotherapy within 4 weeks before enrollment;
• •Age 18-75 years old, physical condition score ECOG 0-1 points;
• •At least one target lesion measurable by imaging within 3 weeks before enrollment, ordinary CT scan ≥ 20 mm, spiral CT scan diameter ≥ 10 mm (lymph node short diameter ≥ 15 mm);
• •Asymptomatic brain metastases, or patients with stable disease for more than 4 weeks after brain metastases treatment;
• •Neurological lesions should be less than grade 2 within 4 weeks before enrollment (NCI CTC4.03);
• •Routine blood and blood biochemical tests were basically normal within 1 week before enrollment (based on the normal value of the research center laboratory, no blood transfusion within 14 days before screening, and no rhG-CSF was used):
• •Blood routine: HGB≥9g/dL; ANC≥1.5×109/L; PLT≥80×109/L; Blood biochemistry (without ALB infusion within 14 days): bilirubin \<1.5 times the upper limit of normal, ALT and AST ≤2.5 times the upper limit of normal (if liver metastases exist, bilirubin ≤3 times the upper limit of normal, ALT and AST≤3 times the upper limit of normal) 5 times the upper limit of normal), serum Cr≤1.5 times the upper limit of normal or endogenous creatinine clearance ≥45 mL/min (Cockcroft-Gault formula);
• •Those who have no major organ dysfunction and no concomitant heart disease;
• •Females of childbearing age, including those who are in menopause but have not reached postmenopausal state (natural amenorrhea for 12 consecutive months) and who have not received sterilization and ovarian and/or hysterectomy, must have a blood pregnancy test within 7 days before the first