Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Vanderbilt University Medical Center
Age
18–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Subjects age 18 to 85 years
On thrice-weekly hemodialysis for at least six months
Clinically stable, adequately dialyzed (single-pool Kt/V \> 1.2), with polysulphone membrane for at least three consecutive months before the study
Subjects with pre-dialytic systolic blood pressure between 110 and 170 mmHg.
Subjects with a reduction of systolic blood pressure during hemodialysis equal to or greater than 30 mmHg, with associated symptoms such as nausea, vomiting, muscle cramps, dizziness, or anxiety.
Hypotensive episodes should occur four times or more in four weeks (12 hemodialysis sessions).
You may not be if
Subjects with intradialytic hypotension that require the use of pharmacological intervention such as midodrine or vasopressin
Subjects with pre-dialytic systolic blood pressure greater than 170 mmHg or diastolic blood pressure greater than 110 mmHg
History of myocardial infarction or cerebrovascular event within 3 months
History of serious hemorrhage (including cerebral hemorrhage) in the past 6 months
Advanced liver disease
Ejection fraction less than 30%
Anticipated live donor kidney transplant
A history of poor adherence to hemodialysis or medical regimen
Severe anemia (hemoglobin less than 8 g/dl) requiring blood transfusions
Use of immunosuppressive drugs within one month before study enrollment
Active connective tissue disease
History of acute infections disease within one month before study enrollment
