Effect of Tiotropium Bromide Combined With Odaterol on Small Airway Remodeling in Patients With Mild to Moderate Chronic Obstructive Pulmonary Disease

Exclusion Criteria

• •Patients with asthma, active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, pulmonary fibrosis, pulmonary hypertension, pulmonary embolism, bronchiolitis obliterans, paradoxical bronchospasm;
• •Patients with blood eosinophilia;
• •Patients with upper respiratory tract infection;
• •Patients with liver or renal insufficiency;
• •Patients with severe unstable systemic diseases or malignant tumors;
• •Patients with glaucoma, benign prostatic hyperplasia or bladder neck obstruction;
• •Patients with hypokalemia, hyperglycemia, diabetes, ketoacidosis or other serious systemic diseases such as heart, brain, liver, kidney, digestive system, endocrine system, immune system, blood;
• •Women of childbearing age who are pregnant, lactating or plan to become pregnant;
• •Patients who have undergone previous pneumonectomy or received lung volume reduction surgery within 12 months before screening;
• •Patients with mental illness;
• •Patients who have participated in other clinical trials within 3 months before screening;
• •Allergic constitution or known allergy to atropine or its derivatives (such as isopropylamine or oxytoluium) Or those who are allergic to the intervention drugs and their ingredients;
• •The researchers believe that it is not appropriate to participate in this clinical trial.