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Improving Antibiotic Stewardship for Children With Respiratory Illness Presenting to Village Health Workers in Uganda | Clinical Trials | Clareo Health

COMPLETEDNA

Improving Antibiotic Stewardship for Children With Respiratory Illness Presenting to Village Health Workers in Uganda

STewardship for Acute Respiratory Illness (STAR): a Stepped Wedge, Cluster Randomized Trial of Point-of-care Biomarker Testing by Village Health Workers

NCT05294510•University of North Carolina, Chapel Hill

View on ClinicalTrials.gov

Summary

This is a stepped wedge, cluster randomized study of a clinical algorithm that includes point-of-care C-reactive protein testing to inform antibiotic treatment decisions by village health workers for children presenting with acute respiratory illness in the Bugoye sub-county of the Kasese District in southwestern Uganda. The purpose of this study is to assess the impact of the algorithm on antibiotic use.

Eligibility

Age

0 - 5 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age 2 months-5 years
•Evaluated by a study VHW in one of the participating villages in Bugoye sub-county for acute respiratory illness defined as the following: fever (documented (temperature \> 38°C) or subjective fever in the last seven days) AND fast breathing (respiratory rate \> 30) OR cough

Exclusion Criteria

•Age \> 5 years or \< 2 months at time of presentation
•Guardian not present to provide consent

Locations (1)

Bugoye Health Center III

Bugoye, Kasese District, Uganda

Key Dates

Start Date

November 2, 2021

Primary Completion Date

May 30, 2022

Completion Date

May 30, 2022

Last Updated

August 4, 2022

Enrollment

1,280

ACTUAL participants

Conditions

Respiratory Infections in Children

Interventions

STAR Sick Child Job Aid

OTHER

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Efficacy of Probiotics (LiveSpo Navax) in Preventing Respiratory Diseases in Children

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Respiratory DiseaseRespiratory Infections in Children

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 4, 2022Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Improving Antibiotic Stewardship for Children With Respiratory Illness Presenting to Village Health Workers in Uganda

Inclusion Criteria

Exclusion Criteria

Trial of an AI-enabled Digital Stethoscope to Improve Antibiotic Stewardship

Efficacy of Probiotics (LiveSpo Navax) in Preventing Respiratory Diseases in Children

Impact of the Use of CRP on the Prescription of Antibiotics in General Practitioners

Probiotics, Respiratory and Intestinal Microbiome and Respiratory Tract Infections in Children