Finding studies
Finding studies
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Lead
Boston Medical Center
With
The primary aims of the research are to evaluate, in patients presenting with posterior artery occlusion (PCA), whether favorable outcome would be superior for EVT compared to Medically Management (MM), inclusive of intravenous thrombolysis (IVT), as measured by: * 90-day modified Rankin Scale (mRS) ordinal shift or * decrease in NIH Stroke Scale/Score (NIHSS) by two points at 24 hours or at hospital discharge The secondary aims are to evaluate in patients presenting with PCA occlusion, other outcome and safety metrics: * 90-day functional independence, mRS 0-2 * 90-day excellent outcome, mRS 0-1 * Visual field recovery (none, partial, complete) by 90-days * rate of reperfusion by modified thrombolysis in cerebral infarction (TICI) scale grade * any intracranial hemorrhage * symptomatic intracranial hemorrhage * mortality In subgroup analysis, the investigators aim to identify subgroups that may confer differential treatment benefit by: * location of occlusion on the PCA segment (P1, P2, P3) * NIHSS strata (0-6, 7-15,\>16) * time from symptom onset to treatment (0 to \<6h vs 6-24h) * posterior circulation (PC) Acute Stroke Prognosis Early Computed Tomography Score (ASPECTS) * visual field defect on presentation The investigators hypothesize that greater benefit in outcomes would be seen in EVT treated patients with higher NIHSS, more proximal PCA occlusion, higher PC ASPECTS scores, and shorter time from symptom onset to treatment.
Age
18–89
Sex
ALL
Healthy volunteers
Not accepted
