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DSUVIA Early Evaluation of Pain Trial | Clinical Trials | Clareo Health

COMPLETEDPHASE3

DSUVIA Early Evaluation of Pain Trial

DSUVIA Early Evaluation of PAIN (DEEP) Trial

NCT05288348•Frank Guyette

Summary

Randomized, interventional trial of Emergency Department (ED) administration of DSUVIA (sufentanil) versus standard care pain management comparing pain treatment outcomes in injured patients with moderate to severe pain

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Trauma activation (Level I, II or III)
•2. Age 18-70 years inclusive
•3. Need for pain treatment based upon NRS (0-100) clinical pain measurement ≥ 50
•4. Estimated time in Emergency Department \> 30 minutes following informed consent

Exclusion Criteria

•1. Advanced airway management prior to 1st dose administration
•2. Known allergy to opioids
•3. Known prisoner
•4. Known pregnancy
•5. ED pain medication contraindicated
•6. Significant respiratory depression
•7. Known or suspected gastrointestinal obstruction, including paralytic ileus

Locations (1)

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Key Dates

Start Date

August 5, 2022

Primary Completion Date

January 21, 2024

Completion Date

January 21, 2024

Last Updated

April 30, 2025

Enrollment

150

ACTUAL participants

Conditions

Traumatic Injury

Interventions

Sufentanil 30 MCG Sublingual Tablet

DRUG

standard care pain treatment

DRUG

Pediatric and Caregiver Traumatic Stress Intervention (PACTS)

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Hyperbaric Oxygenation (HBO) in Traumatic Spinal Cord Injury. (EOS) - Pilot Study

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 30, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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DSUVIA Early Evaluation of Pain Trial

Inclusion Criteria

Exclusion Criteria

Pediatric and Caregiver Traumatic Stress Intervention (PACTS)

Evaluation of BE1116 in Patients With Traumatic Injury and Acute Major Bleeding to Improve Survival ( TAP Study )

Hyperbaric Oxygenation (HBO) in Traumatic Spinal Cord Injury. (EOS) - Pilot Study

Non-severe Traumatic Injuries Evaluation Using smartPhone Camera for Extra-hospital Regulation

Prevention of Injury in Military Settings Through the Use of Body Awareness.

Use of Methoxyflurane (Penthrox) as an Antalgic in Hospital Trauma