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Clinical Study On The Improvement Of Rheolytic Thrombectomy For Acute Deep Vein Thrombosis Of Whole Lower Limb By Primary Popliteal Vein Thrombosis Clearance
Ipsilateral popliteal venous the most common access for pharmacomechanical thrombectomy (PMT) in the treatment of acute deep venous thrombosis (DVT), but the result was not satisfactory. The investigators adjust the access to improve the thrombus clearance rate and reduce the incidence of post-thrombotic syndrome (PTS).
Acute deep venous thrombosis (DVT) with whole lower limb involved is associated with significant post thrombotic morbidity. Both of deep venous occlusion and valvar reflux increase the risk for development of post-thrombotic syndrome (PTS). Early removal of iliofemoral thrombosis by pharmacomechanical thrombectomy (PMT) may reduce the incidence of PTS. In general, ipsilateral popliteal venous the most common access for PMT. However, from this approach, it's hard to remove the thrombosis in the distal popliteal vein. So, the investigators hypothesize that the residual thrombus and slow blood-flow in the in-flow may weakened the efficacy of PMT, and by adjusting vein access approach could improve the thrombus clearance rate and reduce the incidence of PTS for whole leg DVT.
Age
18 - 80 years
Sex
ALL
Healthy Volunteers
No
Renji Hospital
Shanghai, Shanghai Municipality, China
Start Date
September 1, 2022
Primary Completion Date
December 31, 2026
Completion Date
December 31, 2027
Last Updated
May 15, 2025
160
ESTIMATED participants
pharmacomechanical thrombectomy (PMT)
DEVICE
Lead Sponsor
RenJi Hospital
Collaborators
NCT07102160
NCT06519435
Data Source & Attribution
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View ClinicalTrials.gov Terms and ConditionsNCT06451003