Dysfunctional endothelium from FECD with few guttata extending beyond 4.5 mm
Peripheral endothelial cell count \>1000 cells/mm2 in at least one quadrant
Good surgical candidate for either procedure as determined by the surgeon
Willingness to participate
Age greater than 18 years
You may not be if
Aphakia, anterior chamber IOL or scleral fixated IOL in study eye prior to or anticipated during EK
Pre-operative central sub-epithelial or stromal scarring that the investigator believes is visually significant and could impact post-operative stromal clarity assessment
Other primary endothelial dysfunction such as PPMD
Visually significant optic nerve or macular pathology
Hypotony (Intraocular pressure \<10mmHg)
Any prior intraocular surgery other than cataract surgery
\>3 clock hours of ANY anterior or posterior synechiae
\>1 quadrant of stromal corneal vascularization
Inability to comply with post-operative instructions (i.e. unable to position)
Pregnancy
Clareo Health | Descemet Endothelial Thickness Comparison Trial II
