Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors

Exclusion Criteria

• •1. Known allergies, hypersensitivity, or intolerance to TNG908 or its excipients
• •2. Uncontrolled intercurrent illness that will limit compliance with the study requirements
• •3. Active infection requiring systemic therapy
• •4. Currently participating in or has planned participation in a study of another investigational agent or device
• •5. Impairment of GI function or disease that may significantly alter the absorption of oral TNG908
• •6. Active prior or concurrent malignancy.
• •7. Central nervous system metastases associated with progressive neurological symptoms
• •8. Current active liver disease from any cause
• •9. Known to be HIV positive, unless all of the following criteria are met:
• •1. CD4+ count ≥300/μL
• •2. Undetectable viral load
• •3. Receiving highly active antiretroviral therapy
• •10. Clinically relevant cardiovascular disease
• •11. A female patient who is pregnant or lactating
• •12. Patient is unwilling or unable to comply with the scheduled visits, drug administration plan, laboratory tests, biopsy, or other study procedures and study restrictions
• •13. Patient has a prior or ongoing clinically significant illness, medical condition, surgical history, physical finding, or laboratory abnormality that, in the investigator's opinion, may affect the safety of the patient or impair the assessment of study results